Ontology highlight
ABSTRACT:
SUBMITTER: Maertens J
PROVIDER: S-EPMC7179282 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Maertens Johan J Logan Aaron C AC Jang Junho J Long Gwynn G Tang Jih-Luh JL Hwang William Y K WYK Koh Liang Piu LP Chemaly Roy R Gerbitz Armin A Winkler Julia J Yeh Su-Peng SP Hiemenz John J Christoph Sandra S Lee Dong-Gun DG Wang Po-Nan PN Holler Ernst E Mielke Stephan S Akard Luke L Yeo Adeline A Ramachandra Sangana S Smith Kristin K Pertel Peter P Segal Florencia F
Antimicrobial agents and chemotherapy 20200324 4
Human cytomegalovirus (HCMV) can cause significant disease in immunocompromised patients, and treatment options are limited by toxicities. CSJ148 is a combination of two anti-HCMV human monoclonal antibodies (LJP538 and LJP539) that bind to and inhibit the functions of viral HCMV glycoprotein B (gB) and the pentameric complex, consisting of glycoproteins gH, gL, UL128, UL130, and UL131. In this phase 2, randomized, placebo-controlled trial, we evaluated the safety and efficacy of CSJ148 for prop ...[more]