Ontology highlight
ABSTRACT:
SUBMITTER: Kumar V
PROVIDER: S-EPMC7179584 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Kumar Vijay V Tang Christie C Bethel Christopher R CR Papp-Wallace Krisztina M KM Wyatt Jacob J Desarbre Eric E Bonomo Robert A RA van den Akker Focco F
Antimicrobial agents and chemotherapy 20200421 5
Ceftobiprole is an advanced-generation broad-spectrum cephalosporin antibiotic with potent and rapid bactericidal activity against Gram-positive pathogens, including methicillin-resistant <i>Staphylococcus aureus</i>, as well as susceptible Gram-negative pathogens, including <i>Pseudomonas</i> sp. pathogens. In the case of <i>Pseudomonas aeruginosa</i>, ceftobiprole acts by inhibiting <i>P. aeruginosa</i> penicillin-binding protein 3 (PBP3). Structural studies were pursued to elucidate the molec ...[more]