Ontology highlight
ABSTRACT:
SUBMITTER: King DT
PROVIDER: S-EPMC4081958 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
King Dustin T DT Lameignere Emilie E Strynadka Natalie C J NC
The Journal of biological chemistry 20140507 27
In bacteria, the synthesis of the protective peptidoglycan sacculus is a dynamic process that is tightly regulated at multiple levels. Recently, the lipoprotein co-factor LpoB has been found essential for the in vivo function of the major peptidoglycan synthase PBP1b in Enterobacteriaceae. Here, we reveal the crystal structures of Salmonella enterica and Escherichia coli LpoB. The LpoB protein can be modeled as a ball and tether, consisting of a disordered N-terminal region followed by a compact ...[more]