Ontology highlight
ABSTRACT:
SUBMITTER: Dai W
PROVIDER: S-EPMC7179937 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20200422 6497
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the etiological agent responsible for the global COVID-19 (coronavirus disease 2019) outbreak. The main protease of SARS-CoV-2, M<sup>pro</sup>, is a key enzyme that plays a pivotal role in mediating viral replication and transcription. We designed and synthesized two lead compounds (<b>11a</b> and <b>11b</b>) targeting M<sup>pro</sup> Both exhibited excellent inhibitory activity and potent anti-SARS-CoV-2 infection activity. The x- ...[more]