Ontology highlight
ABSTRACT:
SUBMITTER: Chen TY
PROVIDER: S-EPMC7180123 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Chen Tzu-Yu TY Chen Jinfeng J Tang Yijie Y Zhou Jiahai J Guo Yisong Y Chang Wei-Chen WC
Angewandte Chemie (International ed. in English) 20200310 19
N-alkylisonitrile, a precursor to isonitrile-containing lipopeptides, is biosynthesized by decarboxylation-assisted -N≡C group (isonitrile) formation by using N-alkylglycine as the substrate. This reaction is catalyzed by iron(II) and 2-oxoglutarate (Fe/2OG) dependent enzymes. Distinct from typical oxygenation or halogenation reactions catalyzed by this class of enzymes, installation of the isonitrile group represents a novel reaction type for Fe/2OG enzymes that involves a four-electron oxidati ...[more]