Ontology highlight
ABSTRACT:
SUBMITTER: Proshlyakov DA
PROVIDER: S-EPMC5352539 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Proshlyakov Denis A DA McCracken John J Hausinger Robert P RP
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20161103 2-3
A wide range of spectroscopic approaches have been used to interrogate the mononuclear iron metallocenter in 2-oxoglutarate (2OG)-dependent oxygenases. The results from these spectroscopic studies have provided valuable insights into the structural changes at the active site during substrate binding and catalysis, thus providing critical information that complements investigations of these enzymes by X-ray crystallography, biochemical, and computational approaches. This mini-review highlights ta ...[more]