Ontology highlight
ABSTRACT:
SUBMITTER: Martinez R
PROVIDER: S-EPMC7180456 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Martínez Regina R Geronimo Bruno Di BD Pastor Miryam M Zapico José María JM Coderch Claire C Panchuk Rostyslav R Skorokhyd Nadia N Maslyk Maciej M Ramos Ana A de Pascual-Teresa Beatriz B
Molecules (Basel, Switzerland) 20200325 7
The design of multitarget drugs (MTDs) has become an innovative approach for the search of effective treatments in complex diseases such as cancer. In this work, we communicate our efforts in the design of multi-targeting histone deacetylase (HDAC) and protein kinase CK2 inhibitors as a novel therapeutic strategy against cancer. Using tetrabromobenzotriazole (TBB) and 2-dimethylamino-4,5,6,7-tetrabromo-benzimidazole (DMAT) as scaffolds for CK2 inhibition, and a hydroxamate to coordinate the zinc ...[more]