Ontology highlight
ABSTRACT:
SUBMITTER: Dobrynin S
PROVIDER: S-EPMC7180620 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20200408 7
Four albumin-nitroxide conjugates were prepared and tested as metal-free organic radical contrast agents (ORCAs) for magnetic resonance imaging (MRI). Each human serum albumin (HSA) carrier bears multiple nitroxides conjugated via homocysteine thiolactones. These molecular conjugates retain important physical and biological properties of their HSA component, and the resistance of their nitroxide groups to bioreduction was retained or enhanced. The relaxivities are similar for these four conjugat ...[more]