Ontology highlight
ABSTRACT:
SUBMITTER: Murphy-Royal C
PROVIDER: S-EPMC7181611 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Nature communications 20200424 1
Astrocytes support the energy demands of synaptic transmission and plasticity. Enduring changes in synaptic efficacy are highly sensitive to stress, yet whether changes to astrocyte bioenergetic control of synapses contributes to stress-impaired plasticity is unclear. Here we show in mice that stress constrains the shuttling of glucose and lactate through astrocyte networks, creating a barrier for neuronal access to an astrocytic energy reservoir in the hippocampus and neocortex, compromising lo ...[more]