Ontology highlight
ABSTRACT:
SUBMITTER: Shen Y
PROVIDER: S-EPMC7181648 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Shen Yifei Y Xu Jingwen J Pan Xiaohui X Zhang Yunkun Y Weng Yiping Y Zhou Dong D He Shisheng S
Cell death & disease 20200424 4
Metabolic switch from oxidative phosphorylation to aerobic glycolysis, which is also called the Warburg effect, is a hallmark of osteosarcoma (OS) and leads to the enhancement of cell chemoresistance, growth, metastasis, and invasion. Emerging evidence indicates that long non-coding RNA (lncRNA) plays a crucial role in the Warburg effect of cancer cells. Here, we report that lncRNA KCNQ1OT1 was upregulated in OS. Meanwhile, functional experiments demonstrated that the KCNQ1OT1 facilitated prolif ...[more]