Unknown

Dataset Information

0

RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57Kip2 by an m5C-dependent manner.

ABSTRACT: The RNA methyltransferase NSUN2 has been involved in the cell proliferation and senescence, and is upregulated in various types of cancers. However, the role and potential mechanism of NSUN2 in gastric cancer remains to be determined. Our study showed that NSUN2 was significantly upregulated in gastric cancers, compared to adjacent normal gastric tissues. Moreover, NSUN2 could promote gastric cancer cell proliferation both in vitro and in vivo. Further study demonstrated that CDKN1C (p57Kip2) was the potential downstream gene of regulated by NSUN2 in gastric cancer. NSUN2 could promote gastric cancer cell proliferation through repressing p57Kip2 in an m5C-dependent manner. Our findings suggested that NSUN2 acted as an oncogene through promoting gastric cancer development by repressing p57Kip2 in an m5C-dependent manner, which may provide a novel therapeutic target against gastric cancer.

SUBMITTER: Mei L 

PROVIDER: S-EPMC7181747 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57<sup>Kip2</sup> by an m<sup>5</sup>C-dependent manner.

Mei Lin L   Shen Cheng C   Miao Ran R   Wang Jing-Zi JZ   Cao Mend-Da MD   Zhang Yi-Sheng YS   Shi Liang-Hui LH   Zhao Guo-Hai GH   Wang Ming-Hai MH   Wu Li-Sheng LS   Wei Ji-Fu JF  

Cell death & disease 20200424 4

The RNA methyltransferase NSUN2 has been involved in the cell proliferation and senescence, and is upregulated in various types of cancers. However, the role and potential mechanism of NSUN2 in gastric cancer remains to be determined. Our study showed that NSUN2 was significantly upregulated in gastric cancers, compared to adjacent normal gastric tissues. Moreover, NSUN2 could promote gastric cancer cell proliferation both in vitro and in vivo. Further study demonstrated that CDKN1C (p57<sup>Kip  ...[more]

Similar Datasets

Unknown 5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m5C reader.
| S-EPMC5594206 | biostudies-literature
Unknown RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence.
| S-EPMC4991368 | biostudies-literature
Unknown NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation.
| S-EPMC8429414 | biostudies-literature
Unknown Aurora-B regulates RNA methyltransferase NSUN2.
| S-EPMC1805108 | biostudies-literature
Unknown Long noncoding RNA ZFAS1 promotes gastric cancer cells proliferation by epigenetically repressing KLF2 and NKD2 expression.
| S-EPMC5503528 | biostudies-literature
Unknown The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer.
| S-EPMC7463552 | biostudies-literature
Unknown The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate.
| S-EPMC3228827 | biostudies-literature
Unknown The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability.
| S-EPMC2712989 | biostudies-literature
Unknown Long noncoding RNA LINC00337 promote gastric cancer proliferation through repressing p21 mediated by EZH2.
| S-EPMC6556650 | biostudies-literature
Unknown N(6)-adenosine-methyltransferase-14 promotes glioma tumorigenesis by repressing argininosuccinate synthase 1 expression in an m6A-dependent manner.
| S-EPMC8805915 | biostudies-literature