Ontology highlight
ABSTRACT:
SUBMITTER: Iyer S
PROVIDER: S-EPMC7181796 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Iyer Sweta S Uren Rachel T RT Dengler Michael A MA Shi Melissa X MX Uno Etsuko E Adams Jerry M JM Dewson Grant G Kluck Ruth M RM
Cell death & disease 20200423 4
BAK and BAX, which drive commitment to apoptosis, are activated principally by certain BH3-only proteins that bind them and trigger major rearrangements. One crucial conformation change is exposure of their BH3 domain which allows BAK or BAX to form homodimers, and potentially to autoactivate other BAK and BAX molecules to ensure robust pore formation and cell death. Here, we test whether full-length BAK or mitochondrial BAX that are specifically activated by antibodies can then activate other B ...[more]