Ontology highlight
ABSTRACT:
SUBMITTER: Cox MA
PROVIDER: S-EPMC7181845 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Cox Maureen A MA Duncan Gordon S GS Lin Gloria H Y GHY Steinberg Benjamin E BE Yu Lisa X LX Brenner Dirk D Buckler Luke N LN Elia Andrew J AJ Wakeham Andrew C AC Nieman Brian B Dominguez-Brauer Carmen C Elford Alisha R AR Gill Kyle T KT Kubli Shawn P SP Haight Jillian J Berger Thorsten T Ohashi Pamela S PS Tracey Kevin J KJ Olofsson Peder S PS Mak Tak W TW
Science (New York, N.Y.) 20190201 6427
Although widely studied as a neurotransmitter, T cell-derived acetylcholine (ACh) has recently been reported to play an important role in regulating immunity. However, the role of lymphocyte-derived ACh in viral infection is unknown. Here, we show that the enzyme choline acetyltransferase (ChAT), which catalyzes the rate-limiting step of ACh production, is robustly induced in both CD4<sup>+</sup> and CD8<sup>+</sup> T cells during lymphocytic choriomeningitis virus (LCMV) infection in an IL-21-d ...[more]