Ontology highlight
ABSTRACT:
SUBMITTER: Olofsson PS
PROVIDER: S-EPMC5513182 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Olofsson Peder S PS Steinberg Benjamin E BE Sobbi Roozbeh R Cox Maureen A MA Ahmed Mohamed N MN Oswald Michaela M Szekeres Ferenc F Hanes William M WM Introini Andrea A Liu Shu Fang SF Holodick Nichol E NE Rothstein Thomas L TL Lövdahl Cecilia C Chavan Sangeeta S SS Yang Huan H Pavlov Valentin A VA Broliden Kristina K Andersson Ulf U Diamond Betty B Miller Edmund J EJ Arner Anders A Gregersen Peter K PK Backx Peter H PH Mak Tak W TW Tracey Kevin J KJ
Nature biotechnology 20160912 10
Blood pressure regulation is known to be maintained by a neuro-endocrine circuit, but whether immune cells contribute to blood pressure homeostasis has not been determined. We previously showed that CD4<sup>+</sup> T lymphocytes that express choline acetyltransferase (ChAT), which catalyzes the synthesis of the vasorelaxant acetylcholine, relay neural signals. Here we show that these CD4<sup>+</sup>CD44<sup>hi</sup>CD62L<sup>lo</sup> T helper cells by gene expression are a distinct T-cell popula ...[more]