Ontology highlight
ABSTRACT:
SUBMITTER: Fragola G
PROVIDER: S-EPMC7181881 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Fragola Giulia G Mabb Angela M AM Taylor-Blake Bonnie B Niehaus Jesse K JK Chronister William D WD Mao Hanqian H Simon Jeremy M JM Yuan Hong H Li Zibo Z McConnell Michael J MJ Zylka Mark J MJ
Nature communications 20200423 1
Topoisomerase 1 (TOP1) relieves torsional stress in DNA during transcription and facilitates the expression of long (>100 kb) genes, many of which are important for neuronal functions. To evaluate how loss of Top1 affected neurons in vivo, we conditionally deleted (cKO) Top1 in postmitotic excitatory neurons in the mouse cerebral cortex and hippocampus. Top1 cKO neurons develop properly, but then show biased transcriptional downregulation of long genes, signs of DNA damage, neuroinflammation, in ...[more]