Dataset Information

Characterizing Emerging Canine H3 Influenza Viruses.

ABSTRACT: The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses (CIVs) have caused many thousands or millions of respiratory infections in dogs in the United States. While no human infections with CIVs have been reported to date, these viruses could pose a zoonotic risk. In these studies, the National Institutes of Allergy and Infectious Diseases (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS) network collaboratively demonstrated that CIVs replicated in some primary human cells and transmitted effectively in mammalian models. While people born after 1970 had little or no pre-existing humoral immunity against CIVs, the viruses were sensitive to existing antivirals and we identified a panel of H3 cross-reactive human monoclonal antibodies (hmAbs) that could have prophylactic and/or therapeutic value. Our data predict these CIVs posed a low risk to humans. Importantly, we showed that the CEIRS network could work together to provide basic research information important for characterizing emerging influenza viruses, although there were valuable lessons learned.

SUBMITTER: Martinez-Sobrido L

PROVIDER: S-EPMC7182277 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Characterizing Emerging Canine H3 Influenza Viruses.

Martinez-Sobrido Luis L Blanco-Lobo Pilar P Rodriguez Laura L Fitzgerald Theresa T Zhang Hanyuan H Nguyen Phuong P Anderson Christopher S CS Holden-Wiltse Jeanne J Bandyopadhyay Sanjukta S Nogales Aitor A DeDiego Marta L ML Wasik Brian R BR Miller Benjamin L BL Henry Carole C Wilson Patrick C PC Sangster Mark Y MY Treanor John J JJ Topham David J DJ Byrd-Leotis Lauren L Steinhauer David A DA Cummings Richard D RD Luczo Jasmina M JM Tompkins Stephen M SM Sakamoto Kaori K Jones Cheryl A CA Steel John J Lowen Anice C AC Danzy Shamika S Tao Hui H Fink Ashley L AL Klein Sabra L SL Wohlgemuth Nicholas N Fenstermacher Katherine J KJ El Najjar Farah F Pekosz Andrew A Sauer Lauren L Lewis Mitra K MK Shaw-Saliba Kathryn K Rothman Richard E RE Liu Zhen-Ying ZY Chen Kuan-Fu KF Parrish Colin R CR Voorhees Ian E H IEH Kawaoka Yoshihiro Y Neumann Gabriele G Chiba Shiho S Fan Shufang S Hatta Masato M Kong Huihui H Zhong Gongxun G Wang Guojun G Uccellini Melissa B MB García-Sastre Adolfo A Perez Daniel R DR Ferreri Lucas M LM Herfst Sander S Richard Mathilde M Fouchier Ron R Burke David D Pattinson David D Smith Derek J DJ Meliopoulos Victoria V Freiden Pamela P Livingston Brandi B Sharp Bridgett B Cherry Sean S Dib Juan Carlos JC Yang Guohua G Russell Charles J CJ Barman Subrata S Webby Richard J RJ Krauss Scott S Danner Angela A Woodard Karlie K Peiris Malik M Perera R A P M RAPM Chan M C W MCW Govorkova Elena A EA Marathe Bindumadhav M BM Pascua Philippe N Q PNQ Smith Gavin G Li Yao-Tsun YT Thomas Paul G PG Schultz-Cherry Stacey S

PLoS pathogens 20200414 4

The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses (CIVs) have caused many thousands or millions of respiratory infections in dogs in the United States. While no human infections with CIVs have been reported to date, these viruses could pose a zoonotic risk. In these studies, the National Institutes of Allergy ...[more]

PMID: 32287326

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Project description:It is evident that the emergence of infectious diseases, which have the potential for spillover from animal reservoirs, pose an ongoing threat to global health. Zoonotic transmission events have increased in frequency in recent decades due to changes in human behavior, including increased international travel, the wildlife trade, deforestation, and the intensification of farming practices to meet demand for meat consumption. Influenza A viruses (IAV) possess a number of features which make them a pandemic threat and a major concern for human health. Their segmented genome and error-prone process of replication can lead to the emergence of novel reassortant viruses, for which the human population are immunologically naïve. In addition, the ability for IAVs to infect aquatic birds and domestic animals, as well as humans, increases the likelihood for reassortment and the subsequent emergence of novel viruses. Sporadic spillover events in the past few decades have resulted in human infections with highly pathogenic avian influenza (HPAI) viruses, with high mortality. The application of conventional vaccine platforms used for the prevention of seasonal influenza viruses, such as inactivated influenza vaccines (IIVs) or live-attenuated influenza vaccines (LAIVs), in the development of vaccines for HPAI viruses is fraught with challenges. These issues are associated with manufacturing under enhanced biosafety containment, and difficulties in propagating HPAI viruses in embryonated eggs, due to their propensity for lethality in eggs. Overcoming manufacturing hurdles through the use of safer backbones, such as low pathogenicity avian influenza viruses (LPAI), can also be a challenge if incompatible with master strain viruses. Non-replicating adenoviral (Ad) vectors offer a number of advantages for the development of vaccines against HPAI viruses. Their genome is stable and permits the insertion of HPAI virus antigens (Ag), which are expressed in vivo following vaccination. Therefore, their manufacture does not require enhanced biosafety facilities or procedures and is egg-independent. Importantly, Ad vaccines have an exemplary safety and immunogenicity profile in numerous human clinical trials, and can be thermostabilized for stockpiling and pandemic preparedness. This review will discuss the status of Ad-based vaccines designed to protect against avian influenza viruses with pandemic potential.

Dataset Information

Characterizing Emerging Canine H3 Influenza Viruses.

Publications

Characterizing Emerging Canine H3 Influenza Viruses.

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