Ontology highlight
ABSTRACT:
SUBMITTER: Chua HC
PROVIDER: S-EPMC7182417 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Chua H C HC Wulf M M Weidling C C Rasmussen L P LP Pless S A SA
Science advances 20200424 17
The sodium leak channel (NALCN) is essential for survival in mammals: NALCN mutations are life-threatening in humans and knockout is lethal in mice. However, the basic functional and pharmacological properties of NALCN have remained elusive. Here, we found that robust function of NALCN in heterologous systems requires co-expression of UNC79, UNC80, and FAM155A. The resulting NALCN channel complex is constitutively active and conducts monovalent cations but is blocked by physiological concentrati ...[more]