Ontology highlight
ABSTRACT:
SUBMITTER: Lebar T
PROVIDER: S-EPMC7182445 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Lebar Tina T Lainšček Duško D Merljak Estera E Aupič Jana J Jerala Roman R
Nature chemical biology 20200106 5
Protein interactions guide most cellular processes. Orthogonal hetero-specific protein-protein interaction domains may facilitate better control of engineered biological systems. Here, we report a tunable de novo designed set of orthogonal coiled-coil (CC) peptide heterodimers (called the NICP set) and its application for the regulation of diverse cellular processes, from cellular localization to transcriptional regulation. We demonstrate the application of CC pairs for multiplex localization in ...[more]