Ontology highlight
ABSTRACT:
SUBMITTER: Nwosu ZC
PROVIDER: S-EPMC7182727 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Nwosu Zeribe Chike ZC Piorońska Weronika W Battello Nadia N Zimmer Andreas David AD Dewidar Bedair B Han Mei M Pereira Sharon S Blagojevic Biljana B Castven Darko D Charlestin Verodia V Holenya Pavlo P Lochead Julia J De La Torre Carolina C Gretz Norbert N Sajjakulnukit Peter P Zhang Li L Ward Matthew H MH Marquardt Jens U JU di Magliano Marina Pasca MP Lyssiotis Costas A CA Sleeman Jonathan J Wölfl Stefan S Ebert Matthias Philip MP Meyer Christoph C Hofmann Ute U Dooley Steven S
EBioMedicine 20200421
<h4>Background</h4>The extracellular signal-regulated kinase (ERK) pathway regulates cell growth, and is hyper-activated and associated with drug resistance in hepatocellular carcinoma (HCC). Metabolic pathways are profoundly dysregulated in HCC. Whether an altered metabolic state is linked to activated ERK pathway and drug response in HCC is unaddressed.<h4>Methods</h4>We deprived HCC cells of glutamine to induce metabolic alterations and performed various assays, including metabolomics (with < ...[more]