Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer.
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ABSTRACT:
SUBMITTER: Bao MH
PROVIDER: S-EPMC8304710 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Publications
Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer.
Bao Macus Hao-Ran MH Wong Carmen Chak-Lui CC
Cells 20210706 7
Hypoxia, low oxygen (O<sub>2</sub>) level, is a hallmark of solid cancers, especially hepatocellular carcinoma (HCC), one of the most common and fatal cancers worldwide. Hypoxia contributes to drug resistance in cancer through various molecular mechanisms. In this review, we particularly focus on the roles of hypoxia-inducible factor (HIF)-mediated metabolic reprogramming in drug resistance in HCC. Combination therapies targeting hypoxia-induced metabolic enzymes to overcome drug resistance will ...[more]
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