Ontology highlight
ABSTRACT:
SUBMITTER: Tognetti S
PROVIDER: S-EPMC7183217 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20200407 16
Adaptation to environmental changes is crucial for cell fitness. In <i>Saccharomyces cerevisiae</i>, variations in external osmolarity trigger the activation of the stress-activated protein kinase Hog1 (high-osmolarity glycerol 1), which regulates gene expression, metabolism, and cell-cycle progression. The activation of this kinase leads to the regulation of G1, S, and G2 phases of the cell cycle to prevent genome instability and promote cell survival. Here we show that Hog1 delays mitotic exit ...[more]