Ontology highlight
ABSTRACT:
SUBMITTER: Dardashti RN
PROVIDER: S-EPMC7184786 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Dardashti Rebecca Notis RN Kumar Shailesh S Sternisha Shawn M SM Reddy Post Sai PS Miller Brian G BG Metanis Norman N
Chemistry (Weinheim an der Bergstrasse, Germany) 20200331 22
Despite their biological importance, post-translationally modified proteins are notoriously difficult to produce in a homogeneous fashion by using conventional expression systems. Chemical protein synthesis or semisynthesis offers a solution to this problem; however, traditional strategies often rely on sulfur-based chemistry that is incompatible with the presence of any cysteine residues in the target protein. To overcome these limitations, we present the design and synthesis of γ-selenolysine, ...[more]