Body Mass Index as a Moderator of Treatment Response to Ketamine for Major Depressive Disorder.

ABSTRACT:

Purpose/background

Major depressive disorder (MDD) and obesity commonly co-occur. We sought to assess the impact of body mass index (BMI) on the acute antidepressant effects of ketamine in patients with treatment-resistant depression.

Methods/procedures

Post hoc analyses were conducted from a multisite, randomized, double-blind, placebo-controlled trial designed to assess the rapid-onset effects of intravenous ketamine. Patients (n = 99) were randomized to a single dose administration of ketamine 0.1 mg/kg (n = 18), ketamine 0.2 mg/kg (n = 20), ketamine 0.5 mg/kg (n = 22), ketamine 1.0 mg/kg (n = 20), or active placebo, midazolam 0.045 mg/kg (n = 19). Patients were stratified for BMI. For patients randomized to ketamine (n = 80), BMI was assessed as a continuous variable and

SUBMITTER: Freeman MP 

PROVIDER: S-EPMC7185034 | biostudies-literature | 2020 May/Jun

REPOSITORIES: biostudies-literature