Ontology highlight
ABSTRACT:
SUBMITTER: Avnir Y
PROVIDER: S-EPMC7185437 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Cell reports 20171201 11
The heavy chain IGHV1-69 germline gene exhibits a high level of polymorphism and shows biased use in protective antibody (Ab) responses to infections and vaccines. It is also highly expressed in several B cell malignancies and autoimmune diseases. G6 is an anti-idiotypic monoclonal Ab that selectively binds to IGHV1-69 heavy chain germline gene 51p1 alleles that have been implicated in these Ab responses and disease processes. Here, we determine the co-crystal structure of humanized G6 (hG6.3) i ...[more]