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Chronic myeloid leukemia-derived extracellular vesicles increase Foxp3 level and suppressive activity of thymic regulatory T cells.

ABSTRACT: Mechanisms driving immunosuppression in chronic myeloid leukemia are mostly unknown. We show that leukemic extracellular vesicles (EVs) target lymphocytes and amplify suppressive function of thymic regulatory T cells, by driving expression of Foxp3 transcription factor. This could facilitate expansion of leukemic cells outside the bone marrow, leading to blast crisis.

SUBMITTER: Swatler J

PROVIDER: S-EPMC7187374 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Chronic myeloid leukemia-derived extracellular vesicles increase Foxp3 level and suppressive activity of thymic regulatory T cells.

Swatler Julian J Dudka Wioleta W Bugajski Lukasz L Brewinska-Olchowik Marta M Kozlowska Ewa E Piwocka Katarzyna K

European journal of immunology 20191205 4

Mechanisms driving immunosuppression in chronic myeloid leukemia are mostly unknown. We show that leukemic extracellular vesicles (EVs) target lymphocytes and amplify suppressive function of thymic regulatory T cells, by driving expression of Foxp3 transcription factor. This could facilitate expansion of leukemic cells outside the bone marrow, leading to blast crisis. ...[more]

PMID: 31758697

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