Prediction and validation of exenatide risk marker effects on progression of renal disease: Insights from EXSCEL.

ABSTRACT:

Aim

To assess whether the previously developed multivariable risk prediction framework (PRE score) could predict the renal effects observed in the EXSCEL cardiovascular outcomes trial using short-term changes in cardio-renal risk markers.

Materials and methods

Changes from baseline to 6 months in HbA1c, systolic blood pressure (SBP), body mass index (BMI), haemoglobin, total cholesterol, and new micro- or macroalbuminuria were evaluated. The renal outcomes were defined as a composite of a sustained 30% or 40% decline in estimated glomerular filtration rate (eGFR) or end-stage renal disease (ESRD). Relationships between risk markers and long-term renal outcomes were determined in patients with type 2 diabetes from the ALTITUDE study using multivariable Cox regression analysis

SUBMITTER: Idzerda NMA 

PROVIDER: S-EPMC7187441 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature