DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones.
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ABSTRACT:
SUBMITTER: Saint-Lu N
PROVIDER: S-EPMC7187614 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
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DAV131A Protects Hamsters from Lethal <i>Clostridioides difficile</i> Infection Induced by Fluoroquinolones.
Saint-Lu Nathalie N Burdet Charles C Sablier-Gallis Frédérique F Corbel Tanguy T Nevière Agathe A Sayah-Jeanne Sakina S Pulse Mark M Weiss William W Ferreira Stéphanie S Andremont Antoine A Mentré France F de Gunzburg Jean J
Antimicrobial agents and chemotherapy 20191220 1
Fluoroquinolone treatments induce dysbiosis of the intestinal microbiota, resulting in loss of resistance to colonization by exogenous bacteria such as <i>Clostridioides difficile</i> that may cause severe diarrhea in humans and lethal infection in hamsters. We show here that DAV131A, a charcoal-based adsorbent, decreases the intestinal levels of the fluoroquinolone antibiotics levofloxacin and ciprofloxacin in hamsters, protects their intestinal microbiota, and prevents lethal infection by <i>C ...[more]
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