RNase E-dependent degradation of tnaA mRNA encoding tryptophanase is prerequisite for the induction of acid resistance in Escherichia coli.
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ABSTRACT:
SUBMITTER: Kanda T
PROVIDER: S-EPMC7188888 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
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RNase E-dependent degradation of tnaA mRNA encoding tryptophanase is prerequisite for the induction of acid resistance in Escherichia coli.
Kanda Takeshi T Abiko Genta G Kanesaki Yu Y Yoshikawa Hirofumi H Iwai Noritaka N Wachi Masaaki M
Scientific reports 20200428 1
Acid-resistance systems are essential for pathogenic Escherichia coli to survive in the strongly acidic environment of the human stomach (pH < 2.5). Among these, the glutamic acid decarboxylase (GAD) system is the most effective. However, the precise mechanism of GAD induction is unknown. We previously reported that a tolC mutant lacking the TolC outer membrane channel was defective in GAD induction. Here, we show that indole, a substrate of TolC-dependent efflux pumps and produced by the trypto ...[more]
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