Ontology highlight
ABSTRACT:
SUBMITTER: Chen H
PROVIDER: S-EPMC4332155 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Molecular systems biology 20150112 1
An essential part of gene expression is the coordination of RNA synthesis and degradation, which occurs in the same cellular compartment in bacteria. Here, we report a genome-wide RNA degradation study in Escherichia coli using RNA-seq, and present evidence that the stereotypical exponential RNA decay curve obtained using initiation inhibitor, rifampicin, consists of two phases: residual RNA synthesis, a delay in the interruption of steady state that is dependent on distance relative to the mRNA ...[more]