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ABSTRACT:
SUBMITTER: Pillaiyar T
PROVIDER: S-EPMC7189012 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20200420
A new, mild and efficient protocol for the synthesis of trifluoromethyl(indolyl)phenylmethanols by the reaction of indoles with a variety of aromatic fluoromethyl ketones in the presence of K<sub>2</sub>CO<sub>3</sub> (15 mol %) and <i>n-</i>Bu<sub>4</sub>PBr (15 mol %) in water. The desired products were obtained in good to excellent yields without requiring a column chromatographic purification. The reusability of the catalytic system and large-scale synthesis of indolyl(phenyl)methanols, whic ...[more]