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An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques.

ABSTRACT: An improved and expedient technique for the synthesis of peptidyl-fluoromethyl ketones is described. The methodology is based on prior coupling of an aspartate fluoromethyl ketone to a linker and mounting it onto resin-bound methylbenzhydrylamine hydrochloride. Subsequently, by utilising standard Fmoc peptide procedures, a number of short Z-protected peptides were synthesised and assessed as possible inhibitors of the main protease from SARS-CoV-2 (3CL^pro).

SUBMITTER: Joshi D

PROVIDER: S-EPMC8185805 | biostudies-literature |

REPOSITORIES: biostudies-literature

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