Ontology highlight
ABSTRACT:
SUBMITTER: Wei Z
PROVIDER: S-EPMC7189096 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Wei Zhuang Z Kim Tae-Sung TS Ahn Jong Il JI Meng Lingjun L Chen Yaozong Y Ryu Eun Kyoung EK Ku Bonsu B Zhou Ming M Kim Seung Jun SJ Bang Jeong Kyu JK van Deursen Jan M JM Park Jung-Eun JE Lee Kyung S KS
Molecular and cellular biology 20200428 10
Cep57 has been characterized as a component of a pericentriolar complex containing Cep63 and Cep152. Interestingly, Cep63 and Cep152 self-assemble into a pericentriolar cylindrical architecture, and this event is critical for the orderly recruitment of Plk4, a key regulator of centriole duplication. However, the way in which Cep57 interacts with the Cep63-Cep152 complex and contributes to the structure and function of Cep63-Cep152 self-assembly remains unknown. We demonstrate that Cep57 interact ...[more]