Ontology highlight
ABSTRACT:
SUBMITTER: Gupta S
PROVIDER: S-EPMC7189735 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Gupta Sounak S Cheville John C JC Jungbluth Achim A AA Zhang Yanming Y Zhang Lei L Chen Ying-Bei YB Tickoo Satish K SK Fine Samson W SW Gopalan Anuradha A Al-Ahmadie Hikmat A HA Sirintrapun Sahussapont J SJ Blum Kyle A KA Lohse Christine M CM Hakimi A Ari AA Thompson R Houston RH Leibovich Bradley C BC Berger Michael F MF Arcila Maria E ME Ross Dara S DS Ladanyi Marc M Antonescu Cristina R CR Reuter Victor E VE
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20190417 9
Amplifications of JAK2, PD-L1, and PD-L2 at 9p24.1 lead to constitutive expression of PD-L1. This, coupled with JAK2-activation dependent upregulation of PD-L1 and adaptive/induced expression leads to higher tumor PD-L1 expression and immune evasion. Renal tumors were therefore evaluated for 9p24.1 amplifications. A combination of next generation sequencing-based copy number analysis, fluorescence in situ hybridization for JAK2/INSL6 and PD-L1/PD-L2 and immunohistochemistry for phospho-STAT3 (do ...[more]