Ontology highlight
ABSTRACT:
SUBMITTER: Joseph RW
PROVIDER: S-EPMC4674298 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Joseph Richard W RW Millis Sherri Z SZ Carballido Estrella M EM Bryant David D Gatalica Zoran Z Reddy Sandeep S Bryce Alan H AH Vogelzang Nicholas J NJ Stanton Melissa L ML Castle Erik P EP Ho Thai H TH
Cancer immunology research 20150825 12
Monoclonal antibodies that target the programmed death-1 (PD-1)-programmed death ligand-1 (PD-L1) axis have antitumor activity against multiple cancers. The presence of sarcomatoid differentiation in renal cell carcinoma (RCC) is associated with resistance to targeted therapy and poor responses to IL2 immunotherapy. Given the aggressive nature of RCC with sarcomatoid differentiation and the exclusion of sarcomatoid histology from metastatic RCC clinical trials, less is understood regarding selec ...[more]