Ontology highlight
ABSTRACT:
SUBMITTER: Goljanek-Whysall K
PROVIDER: S-EPMC7189996 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Goljanek-Whysall Katarzyna K Soriano-Arroquia Ana A McCormick Rachel R Chinda Caroline C McDonagh Brian B
Aging cell 20200415 4
One of the key mechanisms underlying skeletal muscle functional deterioration during aging is disrupted mitochondrial dynamics. Regulation of mitochondrial dynamics is essential to maintain a healthy mitochondrial population and prevent the accumulation of damaged mitochondria; however, the regulatory mechanisms are poorly understood. We demonstrated loss of mitochondrial content and disrupted mitochondrial dynamics in muscle during aging concomitant with dysregulation of miR-181a target interac ...[more]