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MiR-181a Restores Mitochondrial Dynamics in Skeletal Muscle Ageing

ABSTRACT: Global label free analysis of quadricesp skeletal muscle tissue from adult and old mice subjected to 15 min of isometric contractions.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Skeletal Muscle

SUBMITTER: Brian McDonagh

LAB HEAD: Brian McDonagh

PROVIDER: PXD010091 | Pride | 2020-04-15

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	AdultEx_1.mgf	Mgf
	AdultEx_1.msf	Msf
	AdultEx_1.raw	Raw
	AdultEx_2.mgf	Mgf
	AdultEx_2.msf	Msf

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Publications

miR-181a regulates p62/SQSTM1, parkin, and protein DJ-1 promoting mitochondrial dynamics in skeletal muscle aging.

Goljanek-Whysall Katarzyna K Soriano-Arroquia Ana A McCormick Rachel R Chinda Caroline C McDonagh Brian B

Aging cell 20200415 4

One of the key mechanisms underlying skeletal muscle functional deterioration during aging is disrupted mitochondrial dynamics. Regulation of mitochondrial dynamics is essential to maintain a healthy mitochondrial population and prevent the accumulation of damaged mitochondria; however, the regulatory mechanisms are poorly understood. We demonstrated loss of mitochondrial content and disrupted mitochondrial dynamics in muscle during aging concomitant with dysregulation of miR-181a target interac ...[more]

PMID: 32291905

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