Dataset Information

Short term association between ozone and mortality: global two stage time series study in 406 locations in 20 countries.

ABSTRACT:

Objective

To assess short term mortality risks and excess mortality associated with exposure to ozone in several cities worldwide.

Design

Two stage time series analysis.

Setting

406 cities in 20 countries, with overlapping periods between 1985 and 2015, collected from the database of Multi-City Multi-Country Collaborative Research Network.

Population

Deaths for all causes or for external causes only registered in each city within the study period. MAIN OUTCOME MEASURES: Daily total mortality (all or non-external causes only).

Results

A total of 45?165?171 deaths were analysed in the 406 cities. On average, a 10 µg/m³ increase in ozone during the current and previous day was associated with an overall relative risk of mortality of 1.0018 (95% confidence interval 1.0012 to 1.0024). Some heterogeneity was found across countries, with estimates ranging from greater than 1.0020 in the United Kingdom, South Africa, Estonia, and Canada to less than 1.0008 in Mexico and Spain. Short term excess mortality in association with exposure to ozone higher than maximum background levels (70 µg/m³) was 0.26% (95% confidence interval 0.24% to 0.28%), corresponding to 8203 annual excess deaths (95% confidence interval 3525 to 12?840) across the 406 cities studied. The excess remained at 0.20% (0.18% to 0.22%) when restricting to days above the WHO guideline (100 µg/m³), corresponding to 6262 annual excess deaths (1413 to 11?065). Above more lenient thresholds for air quality standards in Europe, America, and China, excess mortality was 0.14%, 0.09%, and 0.05%, respectively.

Conclusions

Results suggest that ozone related mortality could be potentially reduced under stricter air quality standards. These findings have relevance for the implementation of efficient clean air interventions and mitigation strategies designed within national and international climate policies.

SUBMITTER: Vicedo-Cabrera AM

PROVIDER: S-EPMC7190035 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Short term association between ozone and mortality: global two stage time series study in 406 locations in 20 countries.

Vicedo-Cabrera Ana M AM Sera Francesco F Liu Cong C Armstrong Ben B Milojevic Ai A Guo Yuming Y Tong Shilu S Lavigne Eric E Kyselý Jan J Urban Aleš A Orru Hans H Indermitte Ene E Pascal Mathilde M Huber Veronika V Schneider Alexandra A Katsouyanni Klea K Samoli Evangelia E Stafoggia Massimo M Scortichini Matteo M Hashizume Masahiro M Honda Yasushi Y Ng Chris Fook Sheng CFS Hurtado-Diaz Magali M Cruz Julio J Silva Susana S Madureira Joana J Scovronick Noah N Garland Rebecca M RM Kim Ho H Tobias Aurelio A Íñiguez Carmen C Forsberg Bertil B Åström Christofer C Ragettli Martina S MS Röösli Martin M Guo Yue-Liang Leon YL Chen Bing-Yu BY Zanobetti Antonella A Schwartz Joel J Bell Michelle L ML Kan Haidong H Gasparrini Antonio A

BMJ (Clinical research ed.) 20200210

<h4>Objective</h4>To assess short term mortality risks and excess mortality associated with exposure to ozone in several cities worldwide.<h4>Design</h4>Two stage time series analysis.<h4>Setting</h4>406 cities in 20 countries, with overlapping periods between 1985 and 2015, collected from the database of Multi-City Multi-Country Collaborative Research Network.<h4>Population</h4>Deaths for all causes or for external causes only registered in each city within the study period<b>.</b> MAIN OUTCOME ...[more]

PMID: 32041707

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Project description:Although many studies have linked elevations in tropospheric ozone to adverse health outcomes, the effect of long-term exposure to ozone on air pollution-related mortality remains uncertain. We examined the potential contribution of exposure to ozone to the risk of death from cardiopulmonary causes and specifically to death from respiratory causes.Data from the study cohort of the American Cancer Society Cancer Prevention Study II were correlated with air-pollution data from 96 metropolitan statistical areas in the United States. Data were analyzed from 448,850 subjects, with 118,777 deaths in an 18-year follow-up period. Data on daily maximum ozone concentrations were obtained from April 1 to September 30 for the years 1977 through 2000. Data on concentrations of fine particulate matter (particles that are < or = 2.5 microm in aerodynamic diameter [PM(2.5)]) were obtained for the years 1999 and 2000. Associations between ozone concentrations and the risk of death were evaluated with the use of standard and multilevel Cox regression models.In single-pollutant models, increased concentrations of either PM(2.5) or ozone were significantly associated with an increased risk of death from cardiopulmonary causes. In two-pollutant models, PM(2.5) was associated with the risk of death from cardiovascular causes, whereas ozone was associated with the risk of death from respiratory causes. The estimated relative risk of death from respiratory causes that was associated with an increment in ozone concentration of 10 ppb was 1.040 (95% confidence interval, 1.010 to 1.067). The association of ozone with the risk of death from respiratory causes was insensitive to adjustment for confounders and to the type of statistical model used.In this large study, we were not able to detect an effect of ozone on the risk of death from cardiovascular causes when the concentration of PM(2.5) was taken into account. We did, however, demonstrate a significant increase in the risk of death from respiratory causes in association with an increase in ozone concentration.

Dataset Information

Short term association between ozone and mortality: global two stage time series study in 406 locations in 20 countries.

Objective

Design

Setting

Population

Results

Conclusions

Publications

Short term association between ozone and mortality: global two stage time series study in 406 locations in 20 countries.

Similar Datasets

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