Dataset Information

Lateral semi-circular canal asymmetry in females with idiopathic scoliosis.

ABSTRACT: PURPOSE:Adolescent idiopathic scoliosis (AIS) is a three-dimensional spinal structural deformity that occurs in otherwise normal individuals. Although curve progression and severity vary amongst individuals, AIS can lead to significant cosmetic and functional deformity. AIS etiology has been determined to be genetic, however, exact genetic and biological processes underlying this disorder remain unknown. Vestibular structure and function have potentially been related to the etiopathogenesis of AIS. Here, we aimed to characterize the anatomy of the semicircular canals (SCC) within the vestibular system through a novel approach utilizing T2-weighted magnetic resonance images (MRI). METHODS:Three dimensional, MRI-based models of the SCCs were generated from AIS subjects (n = 20) and healthy control subjects (n = 19). Linear mixed models were used to compare SCC morphological measurements in the two groups. We compared side-to-side differences in the SCC measurements between groups (group*side interaction). RESULTS:Side-to-side differences in the lateral SCC were different between the two groups [false discovery rate adjusted p-value: 0.0107]. Orientation of right versus left lateral SCC was significantly different in the AIS group compared to the control group [mean side-to-side difference: -4.1°, 95% CI: -6.4° to -1.7°]. Overall, among subjects in the AIS group, the left lateral SCC tended to be oriented in a more horizontal position than subjects in the control group. SIGNIFICANCE:Asymmetry within the SCCs of the vestibular system of individuals with AIS potentially results in abnormal efferent activity to postural muscles. Consequences of this muscular activity during periods of rapid growth, which often coincides with AIS onset and progression, warrant consideration.

SUBMITTER: Carry PM

PROVIDER: S-EPMC7190182 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Lateral semi-circular canal asymmetry in females with idiopathic scoliosis.

Carry Patrick M PM Duke Victoria R VR Brazell Christopher J CJ Stence Nicholas N Scholes Melissa M Rousie Dominique L DL Hadley Miller Nancy N

PloS one 20200429 4

<h4>Purpose</h4>Adolescent idiopathic scoliosis (AIS) is a three-dimensional spinal structural deformity that occurs in otherwise normal individuals. Although curve progression and severity vary amongst individuals, AIS can lead to significant cosmetic and functional deformity. AIS etiology has been determined to be genetic, however, exact genetic and biological processes underlying this disorder remain unknown. Vestibular structure and function have potentially been related to the etiopathogene ...[more]

PMID: 32349123

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Project description:IntroductionXbaI single nucleotide polymorphism (SNP) (A/G rs934099) in estrogen receptor 1 gene (ESR1) was described to be associated with curve severity in Japanese idiopathic scoliosis (IS) patients and in Chinese patients with both curve severity and predisposition to IS. PvuII SNP (C/T rs2234693) of ESR1 was described to be associated with the occurrence of IS in the Chinese population; however, two replication studies did not confirm the findings. The ESR1 SNPs have never been studied in Caucasian IS patients.MethodsCase-control study. 287 females with IS underwent clinical, radiological and genetic examinations. The patients were divided into three groups according to curve progression velocity: non-progressive IS, slowly progressive IS (progression <1° per month), and rapidly progressive IS (progression ?1° per month). The radiological maximum Cobb angle was measured and surgery rate established. A control group consisted of 182 healthy females.ResultsAll results followed Hardy-Weinberg equilibrium. In the case-control study, genotype frequency in the patients did not differ for the XbaI (AA?=?33.5%, AG?=?49.1%, GG?=?17.4%), nor for the PvuII (TT?=?26.8%, TC?=?50.2%, CC?=?23.0%) comparing to controls (AA?=?33.5%, AG?=?50.5%, GG?=?15.9%) and (TT?=?23.1%, TC?=?51.1%, CC?=?25.8%), respectively, p?=?0.3685, p?=?0.6046. The haplotype frequency for the patients (AT?=?47.1%, GC?=?39.2%, AC?=?8.9%, GT?=?2.8%) did not differ from the controls (AT?=?44.8%, GC?=?37.4%, AC?=?14.0%, GT?=?3.8%), p?=?0.0645. No difference was found either in XbaI (p?=?0.8671) or PvuII (p?=?0.3601) allele distribution between the patients and the controls. In the case study, there was no significant difference in genotype frequency for the non-progressive, slowly progressive, and rapidly progressive scoliosis. No difference was found in genotype or haplotype distribution for the mean maximum Cobb angle or the surgery rate.ConclusionsNo association was found between ESR1 XbaI or ESR1 PvuII SNP and idiopathic scoliosis in Caucasian females. None of the previously reported associations could be confirmed, regarding curve severity, progression or operation rate.

Dataset Information

Lateral semi-circular canal asymmetry in females with idiopathic scoliosis.

Publications

Lateral semi-circular canal asymmetry in females with idiopathic scoliosis.

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