Ontology highlight
ABSTRACT:
SUBMITTER: Butner JD
PROVIDER: S-EPMC7190324 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Butner Joseph D JD Elganainy Dalia D Wang Charles X CX Wang Zhihui Z Chen Shu-Hsia SH Esnaola Nestor F NF Pasqualini Renata R Arap Wadih W Hong David S DS Welsh James J Koay Eugene J EJ Cristini Vittorio V
Science advances 20200429 18
We present a mechanistic mathematical model of immune checkpoint inhibitor therapy to address the oncological need for early, broadly applicable readouts (biomarkers) of patient response to immunotherapy. The model is built upon the complex biological and physical interactions between the immune system and cancer, and is informed using only standard-of-care CT. We have retrospectively applied the model to 245 patients from multiple clinical trials treated with anti-CTLA-4 or anti-PD-1/PD-L1 anti ...[more]