Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC7190335 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Science advances 20200429 18
The orphan nuclear receptor COUP-TFII is expressed at a low level in adult tissues, but its expression is increased and shown to promote progression of multiple diseases, including prostate cancer, heart failure, and muscular dystrophy. Suppression of COUP-TFII slows disease progression, making it an intriguing therapeutic target. Here, we identified a potent and specific COUP-TFII inhibitor through high-throughput screening. The inhibitor specifically suppressed COUP-TFII activity to regulate i ...[more]