Radiation resistance in head and neck squamous cell carcinoma: dire need for an appropriate sensitizer.
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ABSTRACT:
SUBMITTER: Hutchinson MND
PROVIDER: S-EPMC7190570 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Radiation resistance in head and neck squamous cell carcinoma: dire need for an appropriate sensitizer.
Hutchinson Marsha-Kay N D MND Mierzwa Michelle M D'Silva Nisha J NJ
Oncogene 20200310 18
Radiation is a significant treatment for patients with head and neck cancer. Despite advances to improve treatment, many tumors acquire radiation resistance resulting in poor survival. Radiation kills cancer cells by inducing DNA double-strand breaks. Therefore, radiation resistance is enhanced by efficient repair of damaged DNA. Head and neck cancers overexpress EGFR and have a high frequency of p53 mutations, both of which enhance DNA repair. This review discusses the clinical criteria for rad ...[more]
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