Dataset Information

Examining adjuvant radiation dose in head and neck squamous cell carcinoma.

ABSTRACT:

Background

Compare adjuvant radiation dose trends and outcomes in head and neck squamous cell carcinoma (HNSCC).

Methods

Nonmetastatic HNSCCs treated between 2004 and 2014 with primary site surgery, lymph node dissection, and adjuvant radiation were identified in the National Cancer Database. Standard dose radiation (SD-RT) was defined as an equivalent dose in 2?Gy (EQD2) ?56.64 and ?60?Gy and high-dose radiation (HD-RT) as an EQD2 >60 and <70?Gy.

Results

HD-RT was given to 46% of the 15?836 HNSCC patients managed with adjuvant radiation. When adjusted for poor prognostic factors, HD-RT was associated with increased mortality (HR1.09; 95%CI 1.02-1.16). In nonoropharynx or human papillomavirus-negative oropharynx primary that had positive margins, ?5 positive lymph nodes, and/or extranodal extension, HD-RT was still not associated with improved survival (HR 1.01, 95% CI 0.91-1.12).

Conclusions

There was no survival benefit from postoperative dose escalation above EQD2 60?Gy even in a high-risk cohort.

SUBMITTER: Avkshtol V

PROVIDER: S-EPMC7830814 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Publications

Examining adjuvant radiation dose in head and neck squamous cell carcinoma.

Avkshtol Vladimir V Handorf Elizabeth A EA Ridge John A JA Leachman Brooke K BK Liu Jeffrey C JC Bauman Jessica J Galloway Thomas J TJ

Head & neck 20190209 7

<h4>Background</h4>Compare adjuvant radiation dose trends and outcomes in head and neck squamous cell carcinoma (HNSCC).<h4>Methods</h4>Nonmetastatic HNSCCs treated between 2004 and 2014 with primary site surgery, lymph node dissection, and adjuvant radiation were identified in the National Cancer Database. Standard dose radiation (SD-RT) was defined as an equivalent dose in 2 Gy (EQD2) ≥56.64 and ≤60 Gy and high-dose radiation (HD-RT) as an EQD2 >60 and <70 Gy.<h4>Results</h4>HD-RT was given to ...[more]

PMID: 30737968

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Project description:Head and neck squamous cell carcinoma (HNSCC) is the sixth most common form of cancer worldwide. Radiotherapy, with or without surgery, represents the major approach to curative treatment. However, not all tumors are equally sensitive to irradiation. It is therefore of interest to apply newer system biology approaches (e.g., metabolic profiling) in squamous cancer cells with different radiosensitivities in order to provide new insights on the mechanisms of radiation response. In this study, two cultured HNSCC cell lines from the same donor, UM-SCC-74A and UM-SCC-74B, were first genotyped using Short Tandem Repeat (STR), and assessed for radiation response by the means of clonogenic survival and growth inhibition assays. Thereafter, cells were cultured, irradiated and collected for subsequent metabolic profiling analyses using liquid chromatography-mass spectrometry (LC-MS). STR verified the similarity of UM-SCC-74A and UM-SCC-74B cells, and three independent assays proved UM-SCC-74B to be clearly more radioresistant than UM-SCC-74A. The LC-MS metabolic profiling demonstrated significant differences in the intracellular metabolome of the two cell lines before irradiation, as well as significant alterations after irradiation. The most important differences between the two cell lines before irradiation were connected to nicotinic acid and nicotinamide metabolism and purine metabolism. In the more radiosensitive UM-SCC-74A cells, the most significant alterations after irradiation were linked to tryptophan metabolism. In the more radioresistant UM-SCC-74B cells, the major alterations after irradiation were connected to nicotinic acid and nicotinamide metabolism, purine metabolism, the methionine cycle as well as the serine, and glycine metabolism. The data suggest that the more radioresistant cell line UM-SCC-74B altered the metabolism to control redox-status, manage DNA-repair, and change DNA methylation after irradiation. This provides new insights on the mechanisms of radiation response, which may aid future identification of biomarkers associated with radioresistance of cancer cells.

Dataset Information

Examining adjuvant radiation dose in head and neck squamous cell carcinoma.

Background

Methods

Results

Conclusions

Publications

Examining adjuvant radiation dose in head and neck squamous cell carcinoma.

Similar Datasets

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