Ontology highlight
ABSTRACT:
SUBMITTER: Bartoli V
PROVIDER: S-EPMC7190835 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Bartoli Vittorio V Meaker Grace A GA di Bernardo Mario M di Bernardo Mario M Gorochowski Thomas E TE
Nature communications 20200429 1
Synthetic genetic circuits allow us to modify the behavior of living cells. However, changes in environmental conditions and unforeseen interactions with the host cell can cause deviations from a desired function, resulting in the need for time-consuming reassembly to fix these issues. Here, we use a regulatory motif that controls transcription and translation to create genetic devices whose response functions can be dynamically tuned. This allows us, after construction, to shift the on and off ...[more]