Ontology highlight
ABSTRACT:
SUBMITTER: Hao N
PROVIDER: S-EPMC3746486 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Hao Nan N Budnik Bogdan A BA Gunawardena Jeremy J O'Shea Erin K EK
Science (New York, N.Y.) 20130101 6118
Signaling pathways can induce different dynamics of transcription factor (TF) activation. We explored how TFs process signaling inputs to generate diverse dynamic responses. The budding yeast general stress-responsive TF Msn2 acted as a tunable signal processor that could track, filter, or integrate signals in an input-dependent manner. This tunable signal processing appears to originate from dual regulation of both nuclear import and export by phosphorylation, as mutants with one form of regula ...[more]