Ontology highlight
ABSTRACT:
SUBMITTER: Qian S
PROVIDER: S-EPMC7190840 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Qian Shuwen S Pan Jiabao J Su Yan Y Tang Yan Y Wang Yina Y Zou Ying Y Zhao Yaxin Y Ma Hong H Zhang Youyou Y Liu Yang Y Guo Liang L Tang Qi-Qun QQ
Communications biology 20200429 1
Adipocyte cell death is pathologically involved in both obesity and lipodystrophy. Inflammation and pro-inflammatory cytokines are generally regarded as inducers for adipocyte apoptosis, but whether some innate defects affect their susceptibility to cell death has not been extensively studied. Here, we found bone morphogenetic protein receptor type 2 (BMPR2) knockout adipocytes were prone to cell death, which involved both apoptosis and pyroptosis. BMPR2 deficiency in adipocytes inhibited phosph ...[more]