Unknown

Dataset Information

0

Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3.


ABSTRACT: Catecholamines stimulate the mobilization of stored triglycerides in adipocytes to provide fatty acids (FAs) for other tissues. However, a large proportion is taken back up and either oxidized or re-esterified. What controls the disposition of these FAs in adipocytes remains unknown. Here, we report that catecholamines redirect FAs for oxidation through the phosphorylation of signal transducer and activator of transcription 3 (STAT3). Adipocyte STAT3 is phosphorylated upon activation of β-adrenergic receptors, and in turn suppresses FA re-esterification to promote FA oxidation. Adipocyte-specific Stat3 KO mice exhibit normal rates of lipolysis, but exhibit defective lipolysis-driven oxidative metabolism, resulting in reduced energy expenditure and increased adiposity when they are on a high-fat diet. This previously unappreciated, non-genomic role of STAT3 explains how sympathetic activation can increase both lipolysis and FA oxidation in adipocytes, revealing a new regulatory axis in metabolism.

SUBMITTER: Reilly SM 

PROVIDER: S-EPMC7384260 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC10773535 | biostudies-literature
| S-EPMC7190840 | biostudies-literature
| S-EPMC8502775 | biostudies-literature
| S-EPMC3886663 | biostudies-literature
| S-EPMC6336244 | biostudies-literature
| S-EPMC1221169 | biostudies-other
| S-EPMC8111320 | biostudies-literature
| S-EPMC4550852 | biostudies-literature
| S-EPMC1270460 | biostudies-other
| S-EPMC8692896 | biostudies-literature