Ontology highlight
ABSTRACT:
SUBMITTER: Yosten GL
PROVIDER: S-EPMC7190928 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Yosten Gina Lc GL Harada Caron M CM Haddock Chris C Giancotti Luigino Antonio LA Kolar Grant R GR Patel Ryan R Guo Chun C Chen Zhoumou Z Zhang Jinsong J Doyle Timothy M TM Dickenson Anthony H AH Samson Willis K WK Salvemini Daniela D
The Journal of clinical investigation 20200501 5
Treating neuropathic pain is challenging and novel non-opioid-based medicines are needed. Using unbiased receptomics, transcriptomic analyses, immunofluorescence, and in situ hybridization, we found that the expression of the orphan GPCR Gpr160 and GPR160 increased in the rodent dorsal horn of the spinal cord following traumatic nerve injury. Genetic and immunopharmacological approaches demonstrated that GPR160 inhibition in the spinal cord prevented and reversed neuropathic pain in male and fem ...[more]