Ontology highlight
ABSTRACT:
SUBMITTER: Zhou X
PROVIDER: S-EPMC7191000 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Zhou Xin X He Chenxi C Ren Jiangong J Dai Congxin C Stevens Sharon R SR Wang Qianghu Q Zamler Daniel D Shingu Takashi T Yuan Liang L Chandregowda Chythra R CR Wang Yunfei Y Ravikumar Visweswaran V Rao Arvind Uk AU Zhou Feng F Zheng Hongwu H Rasband Matthew N MN Chen Yiwen Y Lan Fei F Heimberger Amy B AB Segal Benjamin M BM Hu Jian J
The Journal of clinical investigation 20200501 5
Lipid-rich myelin forms electrically insulating, axon-wrapping multilayers that are essential for neural function, and mature myelin is traditionally considered metabolically inert. Surprisingly, we discovered that mature myelin lipids undergo rapid turnover, and quaking (Qki) is a major regulator of myelin lipid homeostasis. Oligodendrocyte-specific Qki depletion, without affecting oligodendrocyte survival, resulted in rapid demyelination, within 1 week, and gradually neurological deficits in a ...[more]