Ontology highlight
ABSTRACT:
SUBMITTER: Wiedemann C
PROVIDER: S-EPMC7191308 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in chemistry 20200423
Disulfide bridges establish a fundamental element in the molecular architecture of proteins and peptides which are involved e.g., in basic biological processes or acting as toxins. NMR spectroscopy is one method to characterize the structure of bioactive compounds including cystine-containing molecules. Although the disulfide bridge itself is invisible in NMR, constraints obtained via the neighboring NMR-active nuclei allow to define the underlying conformation and thereby to resolve their funct ...[more]