Ontology highlight
ABSTRACT:
SUBMITTER: Kenney LJ
PROVIDER: S-EPMC7192543 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Kenney Linda J LJ Anand Ganesh S GS
EcoSal Plus 20200101 1
Two-component regulatory systems represent the major paradigm for signal transduction in prokaryotes. The simplest systems are composed of a sensor kinase and a response regulator. The sensor is often a membrane protein that senses a change in environmental conditions and is autophosphorylated by ATP on a histidine residue. The phosphoryl group is transferred onto an aspartate of the response regulator, which activates the regulator and alters its output, usually resulting in a change in gene ex ...[more]